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John Battelle
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Our First DOC Poll: What Experts Bet On for Longevity
Our inaugural DOC Poll asked scientists and leaders which longevity breakthrough feels most attainable within ten years. More than 40 percent chose extending healthy lifespan.
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AI | Welcome Larry Brilliant, M.D., to the DOC 2026 Faculty
Dr. Larry Brilliant, Evity Technologies CEO, and smallpox-eradication veteran joins DOC 2026 Faculty, bringing public health leadership to the intersection of AI and medicine.
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Neurotech | Amy Kruse, Ph.D., Joins DOC 2026 Faculty
Satori Neuro CIO and neuroscientist Amy Kruse, Ph.D., joins DOC 2026 Faculty, bringing DARPA roots and deep expertise in precision neuroscience, neurotech, and brain-computer interfaces.
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Longevity Science | George Yancopoulos, M.D., Ph.D. Named to DOC 2026 Faculty
George Yancopoulos, M.D., Ph.D., Regeneron co-founder and inventor of Dupixent and Eylea, joins the DOC 2026 Faculty as a leader in longevity science.
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DOC 2026 Program Is Live!
The DOC 2026 program is live. Join 300 leaders in longevity, neuroscience, medical AI, and women’s health this October in Sonoma for the summit.
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Women’s Health | Laura Esserman, M.D., MBA Joins DOC 2026 Faculty
Dr. Laura Esserman returns to DOC 2026 to share WISDOM Study findings showing risk-based breast cancer screening is safe, effective, and reduces patient harm.
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Longevity Medicine | DOC Welcomes Shadi Kourosh, M.D., MPH to DOC 2026 Faculty
Dr. Shadi Kourosh, Harvard dermatologist and AAD Board member whose work centers on regenerative aesthetics, skin longevity, and clinical standards, joins the DOC 2026 Faculty.
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Coleen Murphy, Ph.D.: Why We Need a Reproductive Clock
It’s a question both sensitive and crucial for Coleen Murphy, Ph.D., Princeton University’s Professor of Genomics and Molecular Biology: How long can women have children?
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Longevity Medicine | DOC Welcomes Helen Messier, M.D., Ph.D., to its 2026 Faculty
DOC Welcomes immunologist Dr. Helen Messier, M.D., Ph.D., and Chief Medical Officer of Bioscope.AI, to its 2026 Faculty.
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Dr. Helen M. Blau: The Potential to Reverse Muscle Aging
Stanford’s Dr. Helen Blau found an enzyme blocking muscle repair with age — and a drug that could reverse it, impacting muscle wasting and cartilage…
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Dr. Leonard Zon: Cracking the Code on Mutant Stem Cells
Leonard Zon, M.D., the Grousbeck Professor of Pediatric Medicine at Harvard Medical School spoke about his research on stem cell biology at DOC 2025.
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DOC Is Thrilled To Announce Dr. Neil Parikh Assumes Role of Chief Executive Officer
Dr. Neil Parikh joins DOC as Chief Executive Officer, bringing clinical depth, technological fluency, and entrepreneurial range to carry our “Truth in Medicine” mission forward.
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The Promising Terrain of Stem Cells
Harvard Medical School’s Dr. Leonard Zon and Stanford University’s Dr. Helen M. Blau spoke about the promise of stem cells and longevity at DOC 2025.
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Longevity Science | Alec Wade Ginsberg, PharmD Joins DOC 2026 Faculty
Fourth-generation pharmacist, owner and Chief Operating Officer of New York-based C.O. Bigelow Apothecary, America’s oldest pharmacy, Alec Wade Ginsberg’s career is steeped in legacy.
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Longevity Science | Nicole Gaudelli, Ph.D. Named to DOC 2026 Faculty
Nicole Gaudelli, Ph.D., a life sciences Entrepreneur in Residence with Google Ventures and inventor of the Adenine Base Editor (ABE), joins the DOC 2026 Faculty.
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Dr. Eric Verdin: Longevity Patients Are Prescribing Themselves
With longevity medicine, Dr. Eric Verdin, Chief Executive Officer of the Buck Institute for Research on Aging, believes physicians stand at a crossroads.
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Dinner with DOC: All Science, No Bullsh*t
A private dinner brought together physicians, AI pioneers, and research funders to discuss longevity science, AI in clinical care, and the future of medicine.
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Dr. Michael Snyder: Aging Is Not Linear. Neither is Our Health
Our health trajectory does not follow a straight line, says Michael Snyder, Ph.D, the Stanford W. Ascherman Professor in Genetics at Stanford Medicine.
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Call for Applications | DOC 2026 Living Room Lab
We’re now accepting applications for companies interested in being considered for the DOC 2026 Living Room Lab, one of the most distinctive features of DOC.
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Last Chance for 3-Day Passes – DOC 2026
We’re down to fewer than 10 three-day passes for DOC 2026, October 21–23 at Fairmont Sonoma Mission Inn.
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Dinner with DOC – The First In A Series
This week we’re hosting the first in a series of Dinners with DOC, intimate gatherings over great food, excellent wine, and outstanding people.
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Introducing the DOC 2026 Fellows Program in Partnership with The Buck Institute
The DOC Fellows Program is back for 2026, and this year, we’re proud to partner with The Buck Institute to fund the 2026 Fellows Cohort.
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Medical AI | Travis Zack, M.D., Ph.D. Named to DOC 2026 Faculty
r. Travis Zack, Chief Medical Officer at medical AI platform OpenEvidence, is helping to transform how AI can boost patient care.
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Dr. Nicole Sirotin: The Case for Longevity Medicine Standards
Institute for Healthier Living Abu Dhabi CEO Dr. Nicole Sirotin, has helped develop a standards-driven approach to longevity medicine for patient care.
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Longevity Science | Edward Chang, M.D. Joins DOC 2026 Faculty
The far-reaching work of Neurosurgeon and scientist Edward Chang, M.D., includes research into the neural systems that control emotions, learning, movement, and speech.
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Dr. Claire Clelland: From Genetic Mutations to Targeted Cures
Dr. Claire Clelland, UCSF’s John D French Alzheimer’s Foundation Endowed Chair, believes biologic therapies could reach clinical trials faster by testing them with human tissue.
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DOC 2025 Video: Brain Disease Breakthroughs
Dr. Eric Verdin spoke with Dr. Li Gan, Dr. Claire Clelland, and Dr. David Jones on neurodegenerative disease discoveries and novel therapies at DOC 2025.
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Longevity Science | Nir Barzilai, M.D. Joins DOC 2026 Faculty
As Albert Einstein College of Medicine’s Professor of Medicine and Genetics, geroscientist Nir Barzilai, M.D. has shifted how aging and diseases are viewed and treated.
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Longevity Science | Rachel Sarnoff, M.D., M.Sc., Joins DOC 2026 Faculty
The science of the gut-brain connection has shaped Dr. Rachel Sarnoff’s career as a Health Sciences Assistant Professor of Medicine and board-certified internist at UCLA.
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Dr. Li Gan: The Role of Tau and Inflammation in Alzheimer’s Research
Dr. Li Gan of Weill Cornell Medicine is shifting Alzheimer’s research beyond amyloid, focusing on tau protein and inflammation as key drivers of cognitive decline.
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Dr. David Jones: Democratizing Access to Specialized Brain Care
Dr. David Jones, Director of Mayo Clinic’s Neurology Artificial Intelligence Program, developed StateViewer, an AI tool that diagnoses 14 types of dementia using brain scans.
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Dr. Britney Blair: It’s Time to Talk About Sex
To Dr. Britney Blair, Co-Founder and Chief Science Officer of Lover, sex is linked to a decreased risk of anxiety, depression, and even chronic disease.
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DOC 2026 Welcomes ARPA-H Director Dr. Alicia Jackson as Keynote Speaker
A founder, CEO, and researcher, ARPA-H Director Dr. Alicia Jackson brings firsthand experience navigating the challenges of translating scientific breakthroughs into practical applications.
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Dr. George Slavich: How Ten Minutes of Negativity Can Harm The Body
Teaching people how to develop psychosocial resilience may mitigate acute social pain and reduce stressors to improve overall health, says UCLA’ s Dr. George Slavich.
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Dr. Elissa Epel: The Repairing Power of Rest
UCSF’s Dr. Elissa Epel is well-versed in the effects of chronic stress on the body as expressed through biological aging and other impacts, including depression.
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DOC 2025 Video: The Science of Sex, Stress, and Longevity
Dr. Elissa Epel, Dr. Britney Blair, and Dr. George Slavich say roadmaps for a long, happy life involve sex, stress reduction, and a mindfulness practice.
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Dr. Daisy Robinton: ‘We Need Radical Transformation’
In the women’s health space, Dr. Daisy Robinton’s voice is powerful. After selling her company Oviva Therapeutics, she knows the challenges facing women’s health companies.
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Bailey Renger: Improving Breast Cancer Screening and Specificity
A cancer scare sparked Bailey Renger’s decision to found BeSound, a breast imaging company improving detection for women underserved by today’s screening options.
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Dr. Max Allsworth: Detecting Disease Through Breath Analysis
Chief Science Officer of Owlstone Medical Dr. Max Allsworth is working to uncover hidden signs of disease from cirrhosis to cancer from analyzing one’s breath.
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Roma Van der Walt: Creating Optimal Health and Longevity for Women
When Roma Van der Walt, former professional athlete and founder and CEO of Vitelle talks about women’s bodies and physiology, she speaks from experience.
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Dr. Jennifer Garrison: Untangling the Truth About Female Hormone Therapy
USC and UCSF’s Dr. Jennifer Garrison is a champion of bringing clarity to hormone therapy for women, working with others to dispel myths and misconceptions.
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Dr. Kara Goldman: Why Ovarian Health Matters Beyond Fertility Alone
Northwestern University’s Dr. Kara Goldman, understands that the ovary serves as a vehicle for women’s fertility — and provides insights into female longevity and overall…
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Dr. Kari Nadeau: Tracking Hidden Microplastics in Our Bodies
Dr. Kari Nadeau, Harvard’s Chair of the Department of Environmental Health, believes understanding the effect of the microplastics our body ingests and inhales is critical.
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Dr. Stephen Williams: Blood Proteins Reveal Hidden Health Risks
To Dr. Stephen Williams, Chief Medical Officer of Standard BioTools, proteins and their network of patterns hold clues to the health of our bodies.
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Dr. Heather Hirsch: Building a New Model for Menopause Support
Hormone replacement therapy (HRT) for women in menopause serves as a driver for Dr. Heather Hirsch, founder of science-based concierge clinic, The Collaborative.
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DOC 2025 Video: The Next Generation of Biomarkers
Dr. Stephen Williams, Dr. Max Allsworth, and Dr. Kari Nadeau, talk about the secrets held by the human body foretelling potential illness before symptoms appear.
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DOC 2025 Video: Innovative Women’s Health Startups Face Investment Headwinds
Roma Van der Walt, Bailey Renger, and Dr. Daisy Robinton explored opportunities and challenges facing women’s health, including how technology is shifting women’s health care.
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DOC 2025 Video: How To Fuel Longevity
Helyx Health’s Dr. Tony Masri and USC’s Dr. Valter Longo explored the bedrock of longevity science from protein intake to circadian rhythms.
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Brooks Tingle: John Hancock Has Lessons For All Insurers
John Hancock CEO Brooks Tingle reimagined the life insurance model by spotlighting a powerful alignment: What’s good for customers is also good for business.
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Dr. Tony Masri: The Sleep-Longevity Connection Explained
Neurologist Dr. Tony Masri, co-founder and CEO of Helyx Health, believes the quantity and quality of sleep are, in part, the bedrock of our longevity.
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Dr. Valter Longo: Fasting Your Way to Longevity
Reducing caloric intake for a period of time can help extend longevity and fight disease, says Dr. Valter Longo, the Director of USC’s Longevity Institute.
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DOC 2025 VIDEO: The High-Stakes Gamble of Longevity Medicine: Where Breakthrough Science Meets the Wild West
Dr. Nicole Sirotin, Dr. Eric Verdin and Dr. Jordan Shlain talked about the need to balance progress in cutting-edge longevity research while still protecting patients.
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DOC 2025 Video: The Science of Women’s Health Takes Center Stage, Just Before The FDA Acts
Dr. Kara Goldman, Dr. Heather Hirsch, and Dr. Jennifer Garrison spoke with Dr. Stephanie Kuku about the myth’s and misconception’s surrounding hormone therapy.
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DOC 2025 Video: The Power of Aligned Partners
Researchers, physicians, entrepreneurs, and changemakers united around a shared belief: that collective wisdom cuts through healthcare noise to reveal our true north — science.
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VIDEO: That DOC Magic, 2025 Edition
Our videos highlighting DOC 2025 — a taste of the energy, inspiration and also the community that gathered in Wine Country this fall.
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DOC 2025: Dr. Shlain’s Roundup
We covered ten topics at DOC 2025, and the thread running through them all is this: the future of healthcare isn’t waiting for permission.
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Clinical Breakthroughs | Helen M. Blau, Ph.D. Joins DOC 2025 as a Specialist
The pioneering research of Stanford University biologist Helen Blau, Ph.D. centers on stem cells and aging, providing evidence that human cell fate is reprogrammable.
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Clinical Breakthroughs | Brooks Tingle Joins DOC 2025 as a Specialist
John Hancock’s President and CEO Brooks Tingle believes the life insurance industry has a unique opportunity to help customers live longer, healthier, better lives.
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Clinical Breakthroughs | Leonard Zon, M.D. Joins DOC 2025 as a Specialist
Leonard Zon, M.D., Harvard Medical School’s Grousbeck Professor of Pediatric Medicine, is a stem cell pioneer, transforming therapeutic opportunities to treat and cure diseases.
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Welcome Our 2025 DOC Fellows!
We’re thrilled to announce our DOC 2025 Fellows Class, 19 extraordinary entrepreneurs, doctors and academics joining from around the world in Yountville this year.
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Clinical Breakthroughs and AI | David T. Jones, M.D. Joins DOC 2025 Faculty
David T. Jones, M.D., the Director of the Mayo Clinic Neurology Artificial Intelligence Program, has expanded the therapeutics and clinical care of neurodegenerative disorders.
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AI | Anitha Kannan, Ph.D. Joins DOC 2025 as a Specialist
Anitha Kannan, Ph.D., Vice President of AI at Curai Health, is a researcher and leader in applying artificial intelligence to quality healthcare.
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From Personal Loss to Precision Psychiatry: Revolutionizing Mental Health Treatment
Dr. Leanne Williams’ Stanford Et Cere brain imaging technology uses functional MRI to identify subtypes that may underlie biological patterns leading to mental health conditions.
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Clinical Breakthroughs | Heather Hirsch, M.D., M.S., MSCP Joins DOC Faculty
Heather Hirsch, M.D., founder and CEO of The Collaborative, is a perimenopause and menopause expert who advocates for personalized pathways in women’s healthcare.
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Clinical Breakthroughs | John Osborne, M.D. Joins DOC 2025 Faculty
John Osborne, M.D., ClearCardio’s co-founder and CMO, takes an approach to cardiovascular care focused on tracking, treating and preventing heart disease before it strikes.
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Clinical Breakthroughs | Li Gan, Ph.D. Joins DOC 2025 Faculty
Weill Cornell Medicine Neuroscientist Li Gan, Ph.D., is a leading researcher in Alzheimer’s and fundamentally shifting the exploration of treatments for neurodegenerative diseases.
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Finding Signal in the Noise: A Trust Crisis in Medical Science
At DOC 2024, three experts confronted an uncomfortable truth: the biggest threat to medical innovation might be the collapse of trust in legitimate science itself.
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Clinical Breakthroughs | Nicole Sirotin, M.D. Joins DOC 2025 as a Specialist
Nicole Sirotin, M.D., CEO of the Institute for Healthier Living Abu Dhabi, merges research, clinical care, and technology to advance healthy longevity.
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Valley Legend Reid Hoffman Joins DOC 2025 Debate on “When, if ever, will AI replace doctors?”
Entrepreneur Reid Hoffman — LinkedIn co-founder, Inflection AI, Manas AI, early PayPal executive, and Microsoft Board Director — joins us at DOC 2025.
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Clinical Breakthroughs | Claire Clelland, M.D., Ph.D., M.Phil Joins DOC 2025 Faculty
Neurologist Claire Clelland, M.D., Ph.D., researches neurodegenerative diseases at UCSF, where she holds the John D. French Alzheimer’s Foundation Endowed Chair.
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The Neuroscientist’s Digital Prescription
Over half a billion people suffer from what Dr. Adam Gazzaley, neuroscientist at University of California at San Francisco, calls “debilitating effects of impaired cognition.”
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Women’s Health | Kara Goldman, M.D. Joins Doc 2025 Faculty
Clinician and fertility health pioneer Kara Goldman, M.D. conducts trail-breaking research on reproductive longevity as Director of Fertility Preservation at Northwestern University.
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Women’s Health | Roma van der Walt Joins DOC 2025 as a Specialist
Roma van der Walt, founder and CEO of female healthcare firm Vitelle, is transforming health metrics into longevity solutions tailored to female bodies.
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Women’s Health & AI | Bailey Renger Joins DOC 2025 Faculty
As founder and CEO of the healthcare company BeSound, Bailey Renger is shifting how breast cancer can be detected using AI-assisted ultrasound imaging technology.
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The Age Gap Revolution: Predicting Disease Before It Strikes
Dr. Tony Wyss-Coray, D.H. Chen, Distinguished Professor of Neurology and Neurological Sciences at Stanford University, says human organs do not age at the same rate.
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Clinical Breakthroughs | Stephen Williams, M.D., Ph.D. Joins DOC 2025 Faculty
Stephen Williams, Chief Medical Officer of Standard BioTools, oversees Standard BioTools’ SomaScan Platform, a proteomic technology using modified DNA aptamers to bind to specific proteins.
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Clinical Breakthroughs | George Slavich, Ph.D. Joins DOC 2025 Faculty
Founding Director of the Laboratory for Stress Assessment and Research at UCLA, George Slavich investigates how social experiences can affect biological systems and our genome.
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The Money Problem in Healthcare Innovation
The DOC 2024 session ,“What Capital Wants,” brought together healthcare leaders and venture experts to discuss the role of money in the healthcare system.
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Clinical Breakthroughs | Tony Masri, M.D. Joins DOC 2025 Faculty
Neurologist and board-certified sleep specialist Tony Masri, M.D. has dedicated his research and practice to sleep and its effect on overall health.
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Is Aging A Disease? Revisiting DOC’s 2024 Debate
Dr. Karl Pfleger, angel investor and founder of AgingBiotech.info, argues that the question: “Is aging a disease?” is the wrong one to ask.
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The AI Revolution in Healthcare: Vinod Khosla’s Vision
At DOC 2024, legendary venture capitalist Vinod Khosla brought four decades of Silicon Valley wisdom to healthcare’s biggest AI questions.
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Dr. Meagan Wasfy: The Exercise Paradox — When More Isn’t Always Better
Harvard’s Dr. Meagan Wasfy says the biggest health gains come from getting off the couch, with the exact formula mattering less than consistent physical activity.
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Dr Eric Verdin: The Longevity Reality Check
Buck Institute for Research on Aging CEO Dr. Eric Verdin, believes the future involves precision medicine tools that optimize lifespan on an individual basis.
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Dr. Emeran Mayer: Why Your Gut Bacteria May Hold the Key to Solving Chronic Disease
Dr. Emeran Mayer, UCLA gastroenterologist and brain-gut researcher, says modern medicine overlooks 99% of our genomic content, particularly the trillions of microbes in our gut.
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Clinical Breakthroughs | Valter Longo, Ph.D. Joins DOC 2025 Faculty
Dr. Valter Longo, Director of the Longevity Institute at the USC-Leonard David School of Gerontology, is a leading expert in longevity and age-related diseases.
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The DOC 2025 Program Is Live!
We’re excited to release the DOC 2025 Program, including the Great Debate on AI and Medicine, talks on longevity medicine, women’s health, proteomics and more.
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Dr. Arjun Desai on the Sound Revolution: Focused Ultrasound’s Promise
Dr. Arjun (JJ) Desai, Chief Strategic Innovation Officer of Insightec, sees the future of medicine as focused ultrasound, and working to make that a reality.
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The Stem Cell Revolution: From Lab Bench to Bedside
Dr. Leonard Zon, the Grousbeck Professor of Pediatric Medicine at Harvard Medical School, says there’s a lot of information about stem cells — and misinformation…
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Special Preview: This Year’s Living Room Lab
DOC 2025’s Living Room Lab features a growing list of cutting edge diagnostics available to DOC participants, including Dr. Kari Nadeau’s Microplastics Assay Kit.
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Clinical Breakthroughs | Coleen T. Murphy, Ph.D. Joins DOC 2025 Faculty
Dr. Coleen Murphy, Director of the Lewis-Sigler Institute for Integrative Genomics at Princeton, Murphy is identifying cellular mechanisms involved in the aging process.
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Dr. Laura Esserman: Do Better and Reimagine Cancer Care
Dr. Laura Esserman, Director of the UCSF Breast Cancer Center, posed a radical question at DOC 2024: What if we’ve been doing cancer treatment backwards?
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At DOC, We’re All Conversants
We founded DOC to reimagine what professional events can become, starting with the words we use, where everyone is a conversant.
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Longevity Research & Clinical Innovation | Eric Verdin, M.D. Appointed Senior Adviser
We are pleased to announce the appointment of Eric Verdin, M.D., CEO of the Buck Institute for Research on Aging, as DOC’s Senior Adviser.
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Clinical Breakthroughs | Max Allsworth, Ph.D. Joins DOC 2025 Faculty
As Chief Science Officer at medical research firm Owlstone Medical, Dr. Max Allsworth is deciphering details from the body’s breath to uncover diseases within.
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The Real Cancer Breakthrough
Dr. Stephanie Kuku, surgical oncologist and Chief Knowledge Officer at Conceivable Life Sciences, believes the greatest leap in cancer care starts with smarter, AI-powered tools.
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Women’s Health | Daisy Robinton, Ph.D. Joins DOC 2025 Faculty
Daisy Robinton, Ph.D. is singularly focused on a quest to extend ovarian health and longevity, while advocating for all women’s health.
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Longevity | Elissa Epel, Ph.D. Joins DOC 2025 Faculty
Dr. Elissa Epel, Director of UCSF’s Aging Metabolism Emotions Center, studies the intersection of well-being and stress and how they shape us as we age.
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Clinical Breakthroughs | Kari Nadeau, M.D., Ph.D. Joins DOC 2025 Faculty
As Harvard School of Public Health’s Chair of the Department of Environmental Health, Dr. Kari Nadeau investigates how changing behaviors can improve health span.
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AI & Health | Mike Krieger Joins DOC 2025
Please welcome Mike Krieger, Brazilian-born tech innovator, Instagram co-founder and Stanford graduate who has shaped how billions experience technology, to DOC 2025.
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Genomics & Longevity | Michael Snyder, Ph.D. Joins DOC 2025 Faculty
Dr. Michael Snyder, Stanford University School of Medicine’s Director of the Center of Genomics and Personalized Medicine, is a pioneer in “precision medicine.”
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Women’s Health | Britney Blair, Psy.D. Joins DOC 2025 Faculty
Dr. Britney Blair, co-founder of digital platform, Lover, focuses on educating healthcare professionals about female sexual health and is an advocate for women in business.
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Women’s Health | Jennifer Garrison, Ph.D. Joins DOC 2025 Faculty
Dr. Jennifer Garrison, Buck Institute for Research on Aging’s Co-Director of the Center for Healthy Aging in Women, studies how neuropeptide signaling contributes to aging.
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The DOCUMENT Eighth Edition
We’re shaping the DOC 2025 program, which will focus on the science of longevity and feature three thematic pillars: Clinical Breakthroughs, AI, and Women’s Health.
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The DOCUMENT Seventh Edition
DOC 2025’s program, set for October 2025, will be driven by three core focus areas: AI, Longevity, and Women’s Health.
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The DOCUMENT Sixth Edition
DOC’s mission is to unite and catalyze leaders across health, business, and culture to transform healthcare on both personal and societal levels.
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The DOCUMENT Fifth Edition
Three new specialists will join DOC 2024, including venture capital legend Vinod Khosla, Westward co-creator, writer and director Lisa Joy and ARPA’H’s Dr. Darshak Sanghavi.
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The DOCUMENT Fourth Edition
A central feature of the DOC experience, the Living Room Lab will spotlight a highly curated set of science-driven, early-stage healthcare companies.
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The DOCUMENT Third Edition
DOC 2024 will feature six in-depth explorations, four quick lightning talks, intimate table discussions with Faculty, an Oxford-style debate on aging, and participant-led breakout sessions.
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The DOCUMENT Second Edition
We’re excited to share updates and details as we prepare for what promises to be a thoroughly unique inaugural DOC event this fall in Napa.
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The DOCUMENT First Edition
Welcome to the first edition of The DOCUMENT a periodic update for the DOC community.
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